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When dealing with highly potent compounds, it’s critical that failsafe procedures are in place relating to their handling, storage and containment. In order to ensure that the correct procedures are installed and adhered to, a logical system of classifying the potency of the High-Potent API (HPAPI) is needed. At present, there is no official guidance regarding the safe handling of highly potent APIs. As a result, the industry has begun self-regulating itself, with standards developed by SafeBridge® Consultants (http://www.safebridge.com) being the most widely recognized classification system.