Technical / White Paper

How to Simplify Virus Production Process Scale-Up?

Format: PDF file | Document type: Technical / White Paper

ATMI

Discover how to efficiently scale-up vaccine manufacturing processes by moving from 2-D vessels to the Integrity®​ iCELLis®​ series of single-use fixed-bed bioreactors. Learn more about results achieved for several virus production process developments and how the fixed-bed design of the iCELLis bioreactor enables high cell densities to be achieved and maintained. The studies demonstrated that existing processes can easily be transferred to small scale iCELLis systems by keeping same culture parameters and identical ratios for cells/surface and media/cells. When cell culture conditions are optimized, the process is directly scaled to the industrial scale iCELLis bioreactor.

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