Technical / White Paper

Choosing the Right Size Sphere

Published

Format: PDF file | Document type: Technical / White Paper

Choosing the Right Size Sphere

Choosing the right size sugar sphere, for a multiparticulate dosage form is imperative.  Size matters; not only to achieve a robust formulation and efficient processing, but also to ensure reliable and reproducible release profiles.

Smaller size sugar spheres can present disadvantages; they are harder to coat, due to the higher incidence of agglomeration and the larger surface area requires higher weight gain of coatings to achieve similar film thickness.

Using a proprietary Colorcon tool, My Dosage Design™, film thickness and surface area to film thickness ratios can be determined to predict drug release rates with various size sugar spheres. To read more download here..

Related resources from Colorcon Inc.

Show more

Supplier info centre