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Glycosylation of Proteins: Structure & Analysis
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Glycosylation is one of the most widely observed, and structurally diverse, forms of post-translational modification of proteins and glycans have been shown to have a range of specific biological roles.
Mass spectrometry-based techniques provide an extremely powerful tool for glycan characterization and can help to assess and modify the developmental pathway of a therapeutic glycoprotein.
The techniques available can be used to provide as much detail as is needed at each stage of product development and can then be extended, running hand in hand with the development of the product itself.