Modern Chemical Development and cGMP Synthesis: When to use Chiral Chromatography | |
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Chiral chromatography is widely used to make the first few grams of enantiomers, when the compound is needed pure and quickly, without considering future manufacturing. When large scale production is considered, chemists typically look for alternate routes such as diastereoselective crystallizations or asymmetric synthesis, despite the outstanding potential of chiral chromatography in some cases. |
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