The Challenge of Change - Managing Excipients Control
Colorcon
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Silence Therapeutics says extension of RNAi drug delivery collaboration by Dainippon Sumitomo is evidence of technology’s potential.
The Klockner Pentaplast Group has invested $37m (€27m) to expand PVC production capacity and add shrink-label film capabilities at its facilities in Thailand and the US.
A new nano-based coating that is claimed to reduce packaging waste is initially being targeted at the pharmaceutical sector but could be used in chocolate packaging as well, claims the VTT Technical Research Centre of Finland
The market for “nano-enabled” pharmaceutical packaging is growing 16.5 per cent a year and will be worth $8.1bn (€6bn) by 2014 according to new research by iRAP.
Aluminium foil as a packaging solution is marking its centenary in 2010. Stefan Glimm, executive director of the European Aluminium Foil Association (EAFA), reflects on how this packing mainstay continues to build on its ability to provide the highest barrier protection properties while adapting to the needs of the new millennium.
Jazz Pharmaceuticals says that API maker Lonza has terminated a long-term sodium gamma hydroxybutyrate development and supply agreement.
in-PharmaTechnologist presents its latest round up of movements in the pharma sector, including appointments at Epizyme, Pregis, SixLog, Anthera and Cordis.
The WHO has published its views on the production of starting materials in draft guidance which details recommendations to ensure product quality while keeping costs down.
Medivation laid off 23 employees yesterday to cut costs after Dimebon, the Alzheimer’s disease drug the firm is developing with Pfizer, failed to hit efficacy endpoints in a pivotal Phase III study.
RXi Pharmaceuticals has applied its sd-rxRNA to dermal cells, establishing the efficacy of the technology as it seeks to move it on to the next stage of development, a company VP told in-PharmaTechnologist.
Thermo Fisher Scientific will take charge of clinical trial material production at Eli Lilly’s research technology facility in Indianapolis as the pharmaceutical firm further reduces in-house capacity to cut costs.
The European Medicines Agency (EMA) has recommended a recall of Acino’s generic Plavix (clopidogrel bisulfate) because of alleged failings in GMP at the API production facility.
A joint enforcement operation in the US has led to the arrests of two people accused of being involved in supplying counterfeit weight loss medication, including GSK’s Alli (orlistat).
Contract manufacturing organization (CMO) ScinoPharm says strong anticancer API sales and growing demand in Europe and Asia were key to record performance in 2009.
Genzyme receives US Food and Drug Administration (FDA) “consent decree” for troubled Allston manufacturing plant.
The UK budget was “a missed opportunity” to encourage manufacturing, according to UK Chemical Industries Association (CIA), but was free from unexpected tax increases.
GEA Pharma Systems opens new equipment facility in Gujarat, India and stresses price advantages of "low-cost manufacturing base."
The increasing incidence of chronic and “lifestyle” related disorders will fuel demand for inhalable delivery technologies over the next five years, according to a Global Industry Analysts (GIA) report.
Novozymes Biopharma has published data demonstrating the ability of Recombumin , an excipient, to protect against aggregation, oxidation and non-specific adsorption.
in-PharmaTechnologist presents its latest round up of movements in the pharma sector, including a reshuffle at PhRMA and manoeuvring of directors at OSI Pharmaceuticals and Biogen Idec.
The IPEA's issuance of good manufacturing practice (GMP) “certification” is mark of manufacturing quality, says US specialty chemicals supplier W R Grace & Co.
Industrial glass maker Schott ended a “rather difficult” fiscal 2009 with a loss but says rise in drug packaging sales will help drive double-digit earnings growth in current financial year.
GSK has confirmed that material from the PCV1 virus has been detected in Rotarix and, although there is no evidence of a safety risk, the FDA has recommended use is temporarily suspended.
A Ghanian drugmaker will soon start producing generic pharmaceuticals for the West African market, according to investment group Emerging World Pharma.
The shipping requirements of drugs means the TSA’s new law poses unique problems to the pharma industry, according to DHL, but experience of tight regulations should help companies achieve compliance.
Industrial filtration specialist Pall and testing firm Sotax say their new co-marketing deal is only first stage of planned pharmaceutical industry certification solutions partnership.
Dr Reddy’s has made a “significant investment” in an mPEG alcohol production facility in Mexico to strengthen its presence in a sector it believes is on the rise.
The European Parliament’s Committee on Industry, Research and Energy (ITRE) has unanimously approved the falsified medicine opinion authored my Amalia Sartori MEP.
Amcor has dismissed claims that it should pay hundreds of millions of dollars in damages over allegations it took part in a packaging price fixing cartel.
The Botswanan government is seeking to initiate local pharma manufacturing, which would lower drug prices, by entering into public-private partnerships (PPP), according to a report by F&S.
CEO Steffen Mittwich updates in-PharmaTechnologist on Atacama Labs' pneumatic dry granulation (PDG) API processing tech, its deal with German CMO Excella and future development plans.
Millipore has expanded its microbial detection offering with Milliflex Quantum which, it says, enables manufacturers to respond to contamination issues earlier in the drug and vaccine production process.
US pharmaceutical and biotechnology firms spent a record $65bn (€48bn) on drug and vaccine R&D in 2009, says a new study by the Pharmaceutical Research and Manufacturers of America (PhRMA) and bank Burrill & Co.
Ireland must become an R&D hub as well as a drug manufacturing destination to prosper in the increasingly competitive global pharmaceutical market, says industry body PharmaChemical Ireland (PCI).
Prosonix’ new UMAX particle engineering technology is set to “revolutionise” the field of respiratory medicines, according to company CEO David Hipkiss.
China will become the third largest pharmaceutical market in the world in 2011 according to new research by IMS Health, which also increased its list of fast growing, or “pharmerging,” markets from seven to 17.
Compugen has developed a computer-based, in silico system which can assist drug delivery research by identifying peptides that have the potential to penetrate cell membranes.
in-PharmaTechnologist presents its latest round up of movements in the pharma sector, including appointments at Teva, Codexis, Albemarle and BayBio.
US drug giant Pfizer will assess Tekimra Pharmaceuticals’s stable nucleic acid-lipid particle (SNALP) platform for the delivery of siRNA drugs.
GSK, Genentech, BIO and PDA have stated that it is “unnecessarily burdensome” for pandemic production plans to conform to parts of 21 CFR and requested that the FDA revises its draft guidance.
US drugmaker Genzyme has detected an impurity in one vial of the Gaucher’s disease drug Cerezyme produced at its manufacturing facility in Waterford, Ireland.
US Food and Drug Administration (FDA) request for more Afrezza data is not safety related and will not require new clinical trials, says developer MannKind.
Patheon attributes Q1 loss to charges and plant closure costs and says there has been “an encouraging increase in new sales activity” in calendar 2010.
Fresenius Kabi has opened a temperature controlled, high-bay, fully automated warehouse near its manufacturing plant in Austria, according to its partner on the project.
Drug researchers will have greater access to some top selling molecules, including currently patented compounds atorvastatin, sildenafil and celecoxib, thanks to Sigma Aldrich’s new bioactives deal with US drug major Pfizer.
The Chinese government is supporting a $100m (€73m) project to build a contract biologics production facility in Beijing, which, by some measures, would be the largest in Asia.
Merck & Co has joined a coalition to build a vaccine facility which is capable of simultaneously manufacturing multiple products and can quickly switch in response to a crisis.
AstraZeneca targets global generics market in license and supply deal with Indian manufacturer Torrent Pharma.
US devices specialist MedPro Safety Products and Helvoet Pharma have teamed up to develop the former’s range of prefilled safety syringes (PFSS).
Stason Pharmaceuticals’ subsidiary Standard Chem and Pharm will act as primary distributor for the Unitract 1ml safety syringe in China, Japan and Taiwan under a five-year new deal with US delivery device maker Unilife.
DNA sequencing specialist Genewiz has added gene synthesis to its service portfolio, providing researchers with a time- and cost-saving alternative to techniques such as molecular cloning and protein engineering.
Lotus Pharmaceuticals has broken ground on a building complex, housing offices, R&D, production and storage, in Beijing, China.
Abbott is strengthening its multiple sclerosis and oncology pipeline by agreeing to acquire Facet Biotech for a net value of approximately $450m (€330m).
Pharmadule AB is creating a complete modular biologics production facility, which will be 80 per cent completed in its workshop before delivery, to Lithuania-based Silcor Biotech by 2011.
Glycos Biotechnologies has produced lactic acid in a pilot plant using its sustainable technique, successfully scaling up from a laboratory setting to provide an alternate source for the chiral synthon.
Cambridge Major Laboratories (CML), Avantium, Xcelience and Beckloff have formed a consortium to offer tailored, client-focused CMC packages which are particularly suited to atypical compounds.
Isis Biopolymer, a start up developing a wireless drug delivery patch, has received funding of $3m (€2.2m), according to a filing with the US Securities and Exchange Commission (SEC).
Mettler-Toledo CI-Vision has developed a new 360 degree bottle inspection system to spot packaging and labelling defects.
in-PharmaTechnologist presents its latest round up of movements in the pharma sector, including appointments at Agilent Technologies, iBio, Sanofi Aventis and Q Chip.
Synthon has completed the acquisition of Mexico-based Nafar Laboratories, adding to its presence in Latin America which includes recent purchases in Chile and Argentina.
Wacker Chemie AG has expanded its biologics production facility, adding GMP manufacturing capacity and a process development building in response to customer demand.
Payne Security has acquired BP Secure Solutions, adding the UK firm's roster of adhesive security labelling technologies to its drug industry offering.
Xcellerex is using its single use bioreactor system, FlexFactory, to develop a novel manufacturing process for Humacyte’s regenerative medicine candidate.
Inovio Biomedical has developed a hand-held, cordless electroporation device, Cellectra-SP, which it believes is well suited to administering DNA vaccines in mass immunization programmes.
Indian generic drugmaker Aurobindo Pharma officially launched its CRAMS unit AuroSource last week, also unveiling plans for an R&D facility in Pashamylaram near Hyderabad, India.
New Synthemax synthetic growth matrix promises improved scalability for large-scale hESC production which, say developers Geron and Corning, will cut cost of cell therapy manufacture.
Evonik has bought Membrane Extraction Technology (MET), strengthening its pharma and fine chemical separation capabilities and continuing a busy week of acquisitions for the company.
South Africa-based Aspen Pharma is to sell its Brazilian oral solid dosage form manufacturing facility to Strides Arcolab after posting a 15 per cent drop in revenues from Latin America.
Fujifilm has introduced an anti-counterfeiting label, called ForgeGuard, which it claims is the first product with full colour images and text that can be checked using a viewing device.
The US FDA wants to boost the production of cell-based viral vaccines and says new guidance will help manufacturers.
Sanofi Aventis has paid Unilife €10m for exclusive rights to use its Unifill ready-to-fill (RTF) syringe for the delivery of anti-thrombotic agents and vaccines.
Reports suggest that Japanese drugmaker Astellas Pharma has gone to the US courts to prevent takeover target OSI Pharmaceuticals from impeding its efforts just days after it tabled its $3.5bn (€2.5bn) bid.
Bayer Technology Services (BTS) has set up a new Singapore office to provide the regions’ drug and chemicals producers with engineering consultation services and micro reaction technology.
in-PharmaTechnologist presents its latest round up of movements in the pharma sector, including a retirement at Pfizer, a new CEO at B-MS and appointments at Mylan, Archimedes and Kinex.
A significant share of contract API maker ScinoPharm Taiwan is set to change hands after Watson Pharmaceuticals decided to sell its stake to Uni-President Enterprises Corporation.
Merrion Pharmaceuticals’ GIPET technology has been granted US patent protection for use with bisphosphonates.
Evonik Degussa Gmbh has acquired the Amperkat business from HC Starck, enhancing its range of catalysts used in the production of pharmaceuticals and fine chemicals.
PARI Respiratory Equipment has launched its Vios aerosol delivery system to provide a tool for quickly administering treatments to the lungs, with a small particle size and high respirable drug dose.
Stratophase and GSK are part of a consortium developing a multi-parameter device capable of performing the real-time monitoring of key criteria needed to employ QbD in API production.
US FDA clearance for Italian antibiotics production facility is important for global growth says German contract development and manufacturing organisation (CDMO) Haupt Pharma.
German investment group Aurelius AG has acquired French fine chemicals supplier Isochem from state owned firm Groupe SNPE.
iBio has agreed in principle to license its iBioLaunch platform, which uses Nicotiana to produce therapeutics, to G-Con for the development and manufacture of plant-expressed influenza vaccines.
German pharmaceutical firm Merck KGaA says proposed Millipore acquisition will transform its chemicals unit and give it a more balanced business profile.
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