Gelatine capsules are among the most popular single unit dosage forms for drugs (Rx), over-the-counter (OTC) products and food supplements. While hard gelatine capsules are primarily used for powder applications, soft gelatine capsules are the preferred dosage form for liquid, paste-like or oil-based active ingredients. In general, soft shell capsules release their contents within a few minutes. However, certain types of reactive fillings and extreme storage conditions — such as high temperatures and humidity — may cause the gelatine in the capsule to cross-link and harden. This can result in longer dissolution times in the GI tract and in the slower release of active ingredients. To prevent cross-linking, even under the longest and harshest ICH (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use) storage conditions, GELITA has recently introduced GELITA® RXL R2 gelatine, the next generation of its GELITA® RXL product.