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Excipients, raw materials and intermediates

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Nondestructive, single tablet analysis - Metrohm – customized analysis for the pharmaceutical industry

16-Jun-2014 - NIRS Spectroscopy allows rapid (<30 s) and nondestructive screening of solid dosage forms. It requires neither sample preparation nor solvent use. Interferences that derive from scattering are minimized by converting to second-derivative spectra.
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Developing textures with DC Polyols - Roquette

16-Jun-2014 - Different methodologies for assessing the texture and organoleptic properties of chewable polyols-based tablets.
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Determination of moisture in a protein sample using a portable NIR instrument - Thermo Fisher Scientific

03-Jun-2014 - Near infrared spectroscopy has been used effectively to measure moisture in a wide variety of samples. Due to the large overtone band for water in NIR, levels of accuracy tend to be high and limits of detection are lower than...
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BASF Pharma Solutions for Dermal Drug Delivery - BASF SE

03-Jun-2014 - Transdermal drug delivery is an exciting and challenging area. How can skin permeation be improved? What is the key to drug solubilization in transdermal delivery systems? BASF's Skin Delivery platform seeks to provide understanding, solutions and materials for the delivery...
Download now!Technical / white paper

Smart strategies for sustained release matrix tablets: Compritol® 888 ATO - Gattefossé Pharma

19-May-2014 - This white paper gives an overview of how Compritol® 888 ATO provides clinically relevant sustained drug release profiles along with biopharmaceutical, formulation and manufacturing advantages.We provide an insight on formulation critical attributes, how Compritol® can be used in a range...
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Benzocaine Degradation in Orodispersible Tablet (ODT) Platforms - Roquette

12-May-2014 - The goal of this study was to determine the effect of different marketed ODT platforms on the chemical stability of an amino-containing drug.The results showed that the stability of Benzocaine in the ODTs was clearly modified by the composition of...
Download now!Technical / white paper

Elemental Impurity Analysis in Pharmaceuticals - Butterworth

06-May-2014 - A method to identify the presence of heavy metals in pharmaceuticals was introduced in the United States Pharmacopoeia more than 100 years ago. Today pharmaceutical companies are still using essentially the same method, the USP <231> Heavy Metals Limit Test....
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Near-infrared spectroscopy - Metrohm – customized analysis for the pharmaceutical industry

01-May-2014 - NIRSystems Technology:  Improved productivity and faster quality control of starting materials, intermediates and final products. Learn more
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CREMER OLEO has become the holder of the first CEP ever granted for a Medium-Chain Triglyceride (MIGLYOL® 812 N). - CREMER OLEO GmbH & Co. KG

28-Apr-2014 - CREMER OLEO has gathered its activities for the pharmaceutical industry under the roof of CREMER Health, with a strong commitment to quality leadership in Oleoceuticals. Our pharmaceutical excipients for topical, oral and rectal applications as well as our oleo-chemical based active...
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Maximize Excipient Purity to Optimize Efficacy - Croda

14-Apr-2014 - The purity of your excipient can have a profound impact on your formulation’s performance, affecting both the stability of the drug and the final formulation.  Croda’s Super Refined™ range offers the most highly-purified excipients available, providing the power of purity...
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Solving flowability, sticking and hardness problems - Roquette

07-Apr-2014 - The aim of this study was to improve a wet granulation based tablet formulation presenting flowability and sticking problems.A DC based formulation enabled the problems found to be remedied while in addition achieving higher tablet hardness making the film-coating process...
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How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study - BASF SE

26-Mar-2014 - How glass-forming polymers improve bioavailabilityPolymers are essential components of oral solid dosage forms and used as binders, disintegrants or coatings. Given the increase in poorly water-soluble drugs, not only well-known but also specifically designed polymers (e.g. Soluplus®) can be used...
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Film Coating for Taste-masking of an HIV Drug for Pediatrics - Colorcon Inc.

25-Mar-2014 - MSD evaluated several taste-masking options to coat raltegravir granules, for pediatric dosing.  They chose a coating comprised of Surelease®, aqueous ethylcellulose dispersion, in combination with an Opadry® product.  Insoluble in water, ethylcellulose acts as the taste-masking agent by delaying the...
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KLEPTOSE® LINECAPS - New taste-masking solution - Roquette

17-Mar-2014 - The aim of this study was to investigate the taste-masking capacity of different maltodextrin qualities compared to a known taste-masking substance by using an electronic taste sensing system.
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Dow AFFINISOL™ polymers for Solubility Enhancement - Dow Pharma & Food Solutions

12-Mar-2014 - Dow’s AFFINISOL™ line of excipients include AFFINISOL™ HMPCAS for spray drying applications and AFFINISOL™ HPMC for hot melt extrusion (HME) applications. Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight: •...
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Medicated chewing gum. From formulation to finished product - Cafosa

10-Mar-2014 - In this paper, the production of a compressed medicated chewing gum using our Health in Gum® is explained, from formulation point of view to the tips of compression and regulatory. 
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Role of excipients in design of solid amorphous drug dispersions for delivery of poorly water-soluble drugs - Ashland

10-Mar-2014 - Most new drug candidates suffer from poor water- solubility leading to rate limiting dissolution, slow absorption and limited bioavailability. Solid amorphous drug dispersions are most commonly used improve bioavailability by enhancing drug solubility. The selection of the right solid dispersion...
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Enhancing Actives Delivery for Optimal Formulation Efficacy - Croda

24-Feb-2014 - Excipients designed to enhance skin penetration can maximize the efficacy of topical formulations.  Through lipid disruption and skin polarity modification, topical penetration enhancers allow for more targeted API delivery.  Fill out the form for more information
Download now!Technical / white paper

Film Coating for Pediatric Oral Solid Dosage Forms - Colorcon Inc.

14-Jan-2014 - With careful selection, of an appropriate film coating system, pediatric products may be coated with a suitable color while also providing mechanical integrity, gloss and moisture protection to produce a robust tablet that is effective and easily recognized by consumers...
Watch now!On-Demand Supplier Webinar

Solving your sticking problems with Tabletting Science - I Holland Limited

09-Jan-2014 - This webinar looks at why tablet formulations stick to punch tip faces and how to overcome sticking using punch coatings. We will highlight to tablet manufacturers how quickly a solution can be recommended using I Holland's new TSAR model.

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