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Excipients, raw materials and intermediates


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Maximize Excipient Purity to Optimize Efficacy - Croda

14-Apr-2014 - The purity of your excipient can have a profound impact on your formulation’s performance, affecting both the stability of the drug and the final formulation.  Croda’s Super Refined™ range offers the most highly-purified excipients available, providing the power of purity...
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Solving flowability, sticking and hardness problems - Roquette Pharma

07-Apr-2014 - The aim of this study was to improve a wet granulation based tablet formulation presenting flowability and sticking problems.A DC based formulation enabled the problems found to be remedied while in addition achieving higher tablet hardness making the film-coating process...
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How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study - BASF SE

26-Mar-2014 - How glass-forming polymers improve bioavailabilityPolymers are essential components of oral solid dosage forms and used as binders, disintegrants or coatings. Given the increase in poorly water-soluble drugs, not only well-known but also specifically designed polymers (e.g. Soluplus®) can be used...
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Film Coating for Taste-masking of an HIV Drug for Pediatrics - Colorcon

25-Mar-2014 - MSD evaluated several taste-masking options to coat raltegravir granules, for pediatric dosing.  They chose a coating comprised of Surelease®, aqueous ethylcellulose dispersion, in combination with an Opadry® product.  Insoluble in water, ethylcellulose acts as the taste-masking agent by delaying the...
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KLEPTOSE® LINECAPS - New taste-masking solution - Roquette Pharma

17-Mar-2014 - The aim of this study was to investigate the taste-masking capacity of different maltodextrin qualities compared to a known taste-masking substance by using an electronic taste sensing system.
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Dow AFFINISOL™ polymers for Solubility Enhancement - Dow Pharma & Food Solutions

12-Mar-2014 - Dow’s AFFINISOL™ line of excipients include AFFINISOL™ HMPCAS for spray drying applications and AFFINISOL™ HPMC for hot melt extrusion (HME) applications. Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight: •...
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Medicated chewing gum. From formulation to finished product - Cafosa

10-Mar-2014 - In this paper, the production of a compressed medicated chewing gum using our Health in Gum® is explained, from formulation point of view to the tips of compression and regulatory. 
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Role of excipients in design of solid amorphous drug dispersions for delivery of poorly water-soluble drugs - Ashland

10-Mar-2014 - Most new drug candidates suffer from poor water- solubility leading to rate limiting dissolution, slow absorption and limited bioavailability. Solid amorphous drug dispersions are most commonly used improve bioavailability by enhancing drug solubility. The selection of the right solid dispersion...
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Enhancing Actives Delivery for Optimal Formulation Efficacy - Croda

24-Feb-2014 - Excipients designed to enhance skin penetration can maximize the efficacy of topical formulations.  Through lipid disruption and skin polarity modification, topical penetration enhancers allow for more targeted API delivery.  Fill out the form for more information
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Solving your sticking problems with Tabletting Science - I Holland Limited

09-Jan-2014 - This webinar looks at why tablet formulations stick to punch tip faces and how to overcome sticking using punch coatings. We will highlight to tablet manufacturers how quickly a solution can be recommended using I Holland's new TSAR model.
Download now!Technical / white paper

Film Coating for Pediatric Oral Solid Dosage Forms - Colorcon

14-Jan-2014 - With careful selection, of an appropriate film coating system, pediatric products may be coated with a suitable color while also providing mechanical integrity, gloss and moisture protection to produce a robust tablet that is effective and easily recognized by consumers...
Download now!Technical / white paper

Embedding Q and R Practice in Pharma Ingredient Manufacture - Corbion Purac

09-Dec-2013 - A growing amount of Q&R applies to creating pharmaceuticals. Pharmaceutical manufacturers prefer ingredients developed with compliance that exceeds legal requirements. As the Q&R landscape evolves and its complexity deepens, it becomes increasingly challenging for pharmaceutical ingredient manufacturers to achieve a...
Download now!Technical / white paper

Mitigating Medication Errors with Tablet Design - Colorcon

09-Dec-2013 - Medical prescription drug errors by doctors, pharmacists and patients account for 1.5 million incidences of sickness, injuries or deaths in the U.S. each year. Thirty percent of these unnecessary adverse events are attributed to human errors in identifying drugs and...
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Direct Compression Solutions - How to solve capping issues? - Roquette Pharma

25-Nov-2013 - Capping can be a challenging parameter during the tableting step.A study has been performed on a compression simulator to understand this issue and find the best solution. 
Download now!Technical / white paper

NEOBEE® MCTs Enhance Pharmaceutical Bioavailability - Stepan Lipid Nutrition

04-Nov-2013 - An efficient solvent for many lipophylic drugs and vitamins, NEOBEE® MCTs emulsify in aqueous environments and help uptake in intestinal cells. They are odorless, tasteless and extremely stable and offer a safe, versatile, affordable and simple solution for many bioavailability...
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New Guidelines for Stabilization of Proteins by Freeze Drying: Formulation and Process Heresy - Baxter

17-Oct-2013 - Over the years a number of informal guidelines or “rules” for the formulation and processing of proteins for freeze-drying have been developed. However, in recent years it has become obvious that some of these rules need modification. In this presentation,...
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Health in Gum® adapts to direct compression with standard tableting equipment - Cafosa

14-Oct-2013 - Medicated chewing gum (MCG) is considered a valid drug delivery system that releases the APIs (Active Pharmaceutical Ingredient) by chewing. MCG offers a wide range of advantages that makes it an excellent alternative. In fact, chewing gum has been proven...
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Improving API Stability with Increased Excipient Purity - Croda

14-Oct-2013 - Sensitive or unstable APIs can pose formulating challenges when it comes to ensuring their consistent and safe delivery.  Data indicate that the purity level of an excipient can have a notable influence on the stability of pharmaceutical actives.
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Taste-masking performance of new maltodextrins - Roquette Pharma

23-Sep-2013 - API's undesirable taste is one of the most challenging parameters for oral drug delivery systems. This issue is even more critical in the case of paediatric and geriatric populations.  The study evaluates the taste-masking performance of two new maltodextrins with high...
Download now!Application note

Cell Culture Media Identification with Handheld 1064 Nanometer Raman - Rigaku

23-Sep-2013 - Biopharmaceutical production is a rapidly growing and high risk industry. According to a market research report, only three of ten drugs receive market clearance. Cell culture media plays an important role in biopharmaceutical production. Handheld Raman provides the means for...

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