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Maximize Excipient Purity to Optimize Efficacy - Croda

14-Apr-2014 - The purity of your excipient can have a profound impact on your formulation’s performance, affecting both the stability of the drug and the final formulation.  Croda’s Super Refined™ range offers the most highly-purified excipients available, providing the power of purity...
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How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study - BASF SE

26-Mar-2014 - How glass-forming polymers improve bioavailabilityPolymers are essential components of oral solid dosage forms and used as binders, disintegrants or coatings. Given the increase in poorly water-soluble drugs, not only well-known but also specifically designed polymers (e.g. Soluplus®) can be used...
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Film Coating for Taste-masking of an HIV Drug for Pediatrics - Colorcon

25-Mar-2014 - MSD evaluated several taste-masking options to coat raltegravir granules, for pediatric dosing.  They chose a coating comprised of Surelease®, aqueous ethylcellulose dispersion, in combination with an Opadry® product.  Insoluble in water, ethylcellulose acts as the taste-masking agent by delaying the...
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Dow AFFINISOL™ polymers for Solubility Enhancement - Dow Pharma & Food Solutions

12-Mar-2014 - Dow’s AFFINISOL™ line of excipients include AFFINISOL™ HMPCAS for spray drying applications and AFFINISOL™ HPMC for hot melt extrusion (HME) applications. Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight: •...
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Role of excipients in design of solid amorphous drug dispersions for delivery of poorly water-soluble drugs - Ashland

10-Mar-2014 - Most new drug candidates suffer from poor water- solubility leading to rate limiting dissolution, slow absorption and limited bioavailability. Solid amorphous drug dispersions are most commonly used improve bioavailability by enhancing drug solubility. The selection of the right solid dispersion...
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Bioavailability Enhancement Series: Hot-Melt Extrusion - Capsugel

18-Feb-2014 - Hot-melt extrusion (HME) of amorphous solid dispersions is one approach Bend Research uses to address APIs with limited bioavailability due to low solubility and dissolution rates (DCS IIa and IIb). Please join us to discuss solid dispersion formulation selection and...
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New Developments in Controlled Nucleation during Lyophilization - IMA LIFE

08-Jan-2014 - For the past few years, controlled nucleation during the freeze drying process has been a subject of great interest to the bio-pharm community. The potential benefits of enhanced process control, process repeatability, and cycle time reduction are exciting to both...
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Bioavailability Enhancement Series – Nanoparticle Dispersions & Drug Nanocyrstals - Capsugel

06-Jan-2014 - Drug-containing nanoparticles offer the potential for both increased dissolution rate and higher drug activity compared to bulk crystalline drug.  These advantages can improve oral bioavailability of drugs for which absorption is either dissolution-rate-limited (i.e. DCS Class IIa), or solubility-limited (i.e.,...
Download now!Technical / white paper

Film Coating for Pediatric Oral Solid Dosage Forms - Colorcon

14-Jan-2014 - With careful selection, of an appropriate film coating system, pediatric products may be coated with a suitable color while also providing mechanical integrity, gloss and moisture protection to produce a robust tablet that is effective and easily recognized by consumers...
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With Advancia® get the dose right every time! - Rexam Healthcare

02-Dec-2013 - The intranasal route is widely used for both prescription and over-the-counter drugs, as well as for medical devices (saline solutions). Indeed, it is an attractive option for locally acting drugs or systemically acting drugs, as it offers rapid onset of...
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Bioavailability Enhancement: Amorphous Solid Dispersion Formulations Using the Spray Dry - Capsugel

05-Nov-2013 - Amorphous solid dispersion technology has been developed to be a preferred formulation option to improve solubility and dissolution rate of insoluble compounds with a wide range of applicability. When amorphous compounds are delivered orally, their solubility advantage can translate into...
Download now!Technical / white paper

NEOBEE® MCTs Enhance Pharmaceutical Bioavailability - Stepan Lipid Nutrition

04-Nov-2013 - An efficient solvent for many lipophylic drugs and vitamins, NEOBEE® MCTs emulsify in aqueous environments and help uptake in intestinal cells. They are odorless, tasteless and extremely stable and offer a safe, versatile, affordable and simple solution for many bioavailability...
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New Guidelines for Stabilization of Proteins by Freeze Drying: Formulation and Process Heresy - Baxter

17-Oct-2013 - Over the years a number of informal guidelines or “rules” for the formulation and processing of proteins for freeze-drying have been developed. However, in recent years it has become obvious that some of these rules need modification. In this presentation,...
Download now!Technical / white paper

Applying disruptive technologies in mammalian cell line development - Fujifilm

14-Oct-2013 - Biopharmaceutical manufacturers traditionally rely on cell line development (CLD) “platforms” which combine long development timelines with unpredictable and extensive variation. In this review, we describe the current status of CLD and describe emerging technologies which offer the potential of greater...
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Inhalia®. Designed to deliver a consistent dose, every time! - Rexam Healthcare

23-Sep-2013 - Rexam’s precision metering valve platform for pressurized-metered dose inhalers (pMDIs) Inhalia® meets a wide range of requirements and is ideal for all patients, even with infrequent treatment needs, due to its long prime retention, very low leakage and moisture ingress....
Download now!Technical / white paper

Nucleic Acid Amplification Technique for Biosafety - SGS Life Science Services

09-Sep-2013 - Use of cutting-edge NATs reduces the amount of time needed for development and safety testing of novel biotech products. This white paper describes specific NAT applications including the detection of contaminating viruses, mycoplasma & mycobacteria.
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Exploring New Frontiers in Direct to Patient Home Delivery Services for Clinical Trials Materials - Marken

07-Aug-2013 - Exploring New Frontiers in Direct to Patient (DTP) Home Delivery Services for Clinical Trial Materials provides an in-depth look at reasons to consider a DTP solution. Included in the discussion are concerns with the traditional distribution channels, advantages and challenges...
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Novel encapsulation technology for oral delivery - Freund Pharmatec

17-Jun-2013 - The Ethicap® Gel technology offers solutions to many common formulation challenges faced by the pharmaceutical industry for oral drug delivery of new molecular entities or established compounds. For further information, fill out the form opposite.
Download now!Technical / white paper

Biosimilar Development: The Race to Market - SGS

10-Jun-2013 - This article provides an update on the current regulatory situation for biosimilars, and addresses the issues with demonstrating physicochemical similarity, one of the first hurdles prior to biological and clinical testing.
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Reducing Cellular Irritation with a Purified Excipient - Croda

03-Jun-2013 - The improved oxidative stability of Super Refined® Polysorbate 80 significantly reduces the potential for cellular irritation.  As the highest purity polysorbate 80 available, it is ideal for formulating with sensitive APIs across a wide range of dosage forms.  For more...

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