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Choosing the Right Dimension of Purity - Croda
29-Apr-2013 -
Drug active stability and formulation efficacy can be negatively affected by excipient impurity. Additional purity can be valuable in protecting the drug active and overall formulation quality. Studies show that formulas using High Purity® excipients have reduced peroxide and acid...
Case study
ONAMER® M Preservative and Antimicrobial Agent - Stepan
22-Apr-2013 -
ONAMER® M is a biocide agent suitable in a variety of liquid drug formulations. Its high safety and low toxicity profile makes it especially advantageous when contact with sensitive tissues (eye, skin and mucous membranes) is required. It does not...
Research study
Vcaps® Plus capsules: The next generation HPMC capsule for optimum formulation of Pharmaceutical Dosage forms - Capsugel
28-Feb-2013 -
Traditionally, HPMC capsules have been formulated with secondary gelling agents and ionic gel promoters, which may lead to unwanted issues during the product development.Vcaps® Plus HPMC capsules are made through a proprietary manufacturing process that eliminates the need for gelling...
Data sheet
Looking for a high purity topical delivery enhancer? - Croda
25-Feb-2013 -
Improve the delivery of drug actives to the epidermis and maximize the effectiveness of your formulations with Croda’s Super Refined® Arlasolve™ DMI, a superior grade of dimethyl isosorbide. Click here for more information...
Insight guide
Analytical Method Development and Validation — A CDMO Perspective - DPT Labs
05-Dec-2012 -
Pharmaceutical drug product development can be an expensive and time consuming process. Many challenges are faced by pharmaceutical development companies including developing a scaleable, marketable formulation, ensuring safety and efficacy of the drug product and receiving approval of the drug...
Technical / white paper
BASF’s Hot-Melt Extrusion Compendium – 2nd edition - BASF SE
08-Oct-2012 -
The new edition provides readers with an even better understanding of solid dispersions and the hot-melt extrusion process. It offers an overview of BASF’s polymers, more real-world application data and factors to consider in the formulation process
Technical / white paper
COMPENDIUM: Expert advice on solubility enhancement - BASF SE
20-Jun-2012 -
Must-read solubility enhancement compendiumThe result of many years of research, BASF’s solubilization compendium covers basic principles of solubility enhancement, delivering expert advice and practical tips on:
Solubilizing compounds with poor solubility and bioavailability profiles
Creating solid solutions and dispersions
Investigating solubilization efficacy using...
Data sheet
Issues with Cellular Irritation? - Croda
04-Jun-2012 -
Reduce the irritation at the site of injection or application. Croda’s Super Refined Polysorbate 80 has demonstrated significant reduction in polar impurities which result in significant reduction of cellular irritation. Click here for more information.
Technical / white paper
What do physicians think of DPIs? New insights from a recent survey - Capsugel
01-Jun-2012 -
Interest in DPIs as an alternative to traditional pMDIs has burgeoned in recent years following advances in their design and performance. But what do physicians think? In a survey of treating physicians (GPs and lung specialists), there was a general consensus...
Case study
Looking to Improve Your Formulation Stability? - Croda
02-Apr-2012 -
Maximize your API and overall formulation stability with high purity PEG 400. Croda’s Super Refined® PEG 400 has demonstrated it improves API stability as well as reduces gelatin cross-linking. Click here for more information.
Technical / white paper
SGS-Lab-Disulfide Bonds…. - SGS
02-Apr-2012 -
The disulfide bond is a post-translational protein modification with significant implications for structure and function. Predicting the disulfide-bonding pattern in a particular protein poses many analytical challenges as outlined in this article.
Technical / white paper
Container Testing: Quantifying Metal Contaminants - SGS
05-Mar-2012 -
With USP <661> colorimetric methods for detecting heavy metal contaminants known to be inadequate at trace levels, SGS conducted experiments to measure the impact of extraction, solvent, and detection techniques using proposed USP <232> methodology.
Case study
Irritated by Your Topical Formulations? - Croda
05-Mar-2012 -
Don't let your topical formulations irritate you any further. Croda's Super Refined Oleic Acid has demonstrated it reduces cellular irritation as well as improves oxidative stability.
Video
Capsugel's 'All in one solution' for clinical material manufacturing - Capsugel
27-Feb-2012 -
In addition to our DBcaps capsules, designed for over-encapsulation, we offer equipment and technical support for encapsulation of both solid and liquid fills.
The DB Filling system is the latest enhancement for the CAP8 Filling machine. It enables fast and...
Data sheet
A Streamlined Approach for Nasal Spray Development & Manufacturing - DPT Labs
14-Feb-2012 -
Nasal sprays are comprised of one or more therapeutically active ingredients that are either dissolved or suspended in solutions in non‐pressurized dispensers. Because the efficacy of the drug product depends on the ability of the spray device to deliver reproducible...
Case study
Issues with oxidative stability? - Croda
06-Feb-2012 -
Croda has created a Super Refined® Castor Oil that has demonstrated improved oxidative stability for maximizing the stability and integrity of drug actives. If you are working with a sensitive active or formulation, please click here for more information.
Technical / white paper
Sample Prep Proposed USP<233> Elemental Impurities - SGS
30-Jan-2012 -
Proper sample preparation is crucial when analyzing for trace metals using inductively coupled plasma (ICP). This paper illustrates how solubility of the test article may not be the primary factor when choosing a sample preparation method.
Technical / white paper
Inhalation Technology: A breath of fresh air in drug delivery! - Capsugel
29-Nov-2011 -
Inhalation Technology: A breath of fresh air in drug delivery!Inhalation technology is really taking off! Applications for dry powder inhalation (DPI) are expanding from respiratory disease into new, previously inconceivable therapeutic areas to replace more onerous drug regimens and improve...
Research study
Impact of passive safety devices on the prefilled syringes dose delivery - Rexam Healthcare
21-Nov-2011 -
Dose accuracy and consistency are key parameters for the pharmaceutical companies as they have an impact on the treatment efficiency and drug overfilling. This study compares the residual volume of the drug in syringes equipped with passive marketed devices after...
Application note
Monoclonal Antibodies Characterization - SGS
14-Nov-2011 -
A number of new monoclonal antibody products and monoclonal antibody biosimilars are in development, all require extensive characterization to obtain the necessary approvals for clinical trials and eventually marketing approval. Download this paper to read more.
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