Monitoring and controlling pH is a vital part of optimising cell culture performance, product composition and costs but currently available sensors are prone to drift over time, resulting in inaccurate results.

This can be detrimental to product yield and drug potency but Sensorin believes it can now improve the situation with its technology that uses molecular electronics to measure pH.

Reliable pH monitoring

Carolyn Kahn, Sensorin president and CEO, said: “Reliable, in-line, self-calibrating pH monitoring is a key component for achieving Quality by Design and for incorporating Process Analytical Technologies into bioprocessing. Sensorin's novel technology platform enables a new level of control.

“The continuously self-calibrating (CSC) Sensor does not foul or drift, functions in both low and high ionic strength environments, and is designed to integrate with existing pH control equipment. These features make Sensorin's CSC Sensor ideal for deployment within the biopharmaceutical manufacturing setting, as well as in other process applications.”

Sensorin's measurement system has been designed to be unaffected by temperature, pressure and other variables, which can impact on the readings given by alternative devices. In addition the technology does not require calibration by the user, unlike alternative pH sensing systems such as glass electrode, ISFET and optical.