Breaking News on Global Pharmaceutical Technology & Manufacturing

Library > On-Demand Supplier Webinar

Dow AFFINISOL™ polymers for Solubility Enhancement

Format: Webinar | Document type: Supplier Webinar
Dow Pharma & Food Solutions

Dow has developed the AFFINISOL™ line of excipients to enable solubility enhancement.

Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight:

  • Utility of commercial grades of AFFINISOL™ HPMCAS
  • AFFINISOL™ HPMCAS Quality by Design sample sets in the formulation of solid dispersions
  • Innovative high productivity HPMCAS polymer providing similar product performance while reducing solution viscosity allowing for increased solids loading in the feed solution.

AFFINISOL™ HPMC HME provides a broader extrusion operating window, improved melt flow and resistance to color change at elevated temperatures. The study shows:

  • Processing versatility of this polymer in HME
  • Polymer utility in solubility enhancement


  • Kevin O’Donnell

    Kevin O’Donnell

    Associate Research Scientist

    Dow Pharma & Food Solutions

  • William “Trey” Porter III

    William "Trey" Porter III

    Associate Research Scientist

    Dow Pharma & Food Solutions


How food producers can cater to flexitarians

Changes in consumer dietary choices are expanding the market for meat-free products. A growing number of omnivores are cutting back on meat, creating a new class of flexitarians. People in this group want high quality vegetable protein-based products to replace meat in many of their meals. The challenge for food producers is to create meat substitutes that meet these demands while also catering for the overlapping allergen-free market.