Breaking News on Global Pharmaceutical Technology & Manufacturing

Library > On-Demand Supplier Webinar

Dow AFFINISOL™ polymers for Solubility Enhancement

Format: Webinar | Document type: Supplier Webinar
Dow Pharma & Food Solutions

Dow has developed the AFFINISOL™ line of excipients to enable solubility enhancement.

Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. We will highlight:

  • Utility of commercial grades of AFFINISOL™ HPMCAS
  • AFFINISOL™ HPMCAS Quality by Design sample sets in the formulation of solid dispersions
  • Innovative high productivity HPMCAS polymer providing similar product performance while reducing solution viscosity allowing for increased solids loading in the feed solution.

AFFINISOL™ HPMC HME provides a broader extrusion operating window, improved melt flow and resistance to color change at elevated temperatures. The study shows:

  • Processing versatility of this polymer in HME
  • Polymer utility in solubility enhancement


  • Kevin O’Donnell

    Kevin O’Donnell

    Associate Research Scientist

    Dow Pharma & Food Solutions

  • William “Trey” Porter III

    William "Trey" Porter III

    Associate Research Scientist

    Dow Pharma & Food Solutions